RESPIRATORY SYNCYTIAL VIRUS (RSV) NEUTRALIZING ANTIBODY TITERS HUMAN IMMUNE SERUM GLOBULIN FOR INTRAVENOUS (IVIG) INFUSION

Structural basis for immunization with postfusion respiratory syncytial virus fusion F glycoprotein (RSV F) to elicit high neutralizing antibody titers.

Respiratory syncytial virus (RSV), the main cause of infant bronchiolitis, remains a major unmet vaccine need despite more than 40 years of vaccine research. Vaccine candidates based on a chief RSV neutralization antigen, the fusion (F) glycoprotein, have foundered due to problems with stability, purity, reproducibility, and potency. Crystal structures of related parainfluenza F glycoproteins h...

Respiratory syncytial virus-neutralizing serum antibody titers in infants following palivizumab prophylaxis with an abbreviated dosing regimen

BACKGROUND Monthly injections of palivizumab during the respiratory syncytial virus (RSV) season in at-risk infants reduces RSV-associated hospitalizations. However, the additive effect of naturally acquired immunity remains unclear. The objective of this study was to assess total neutralizing serum antibodies (NAb) against RSV in at-risk infants who had received an abbreviated course of palivi...

Respiratory Syncytial Virus (RSV) Infection

Effectiveness of topically administered neutralizing antibodies in experimental immunotherapy of respiratory syncytial virus infection in cotton rats.

Initial studies of the prophylactic effect of parenterally administered respiratory syncytial virus (RSV)-neutralizing antibodies in cotton rats indicated that virus replication in lung tissues was restricted when animals with preexisting antibody titers in serum of 1:100 or more (as measured by plaque reduction) were challenged intranasally with 10(4) PFU of virus. Subsequently, a therapeutic ...

What is respiratory syncytial virus (RSV)?

one of the most common causes of bronchiolitis and pneumonia in children under 1 year of age in the United States. It is a common reason for young infants to be hospitalized during the RSV season. RSV can also cause serious respiratory illness in older adults. Most healthy people recover from RSV infection in 1 to 2 weeks. However, infection can be severe in a few, usually among those who are a...